The latest premiere of the longest-running US medical drama was dedicated to Stephanie Leifer and, while casual fans of the long-running medical drama might not be aware of who she is, the tribute was a moving moment as Leifer was an instrumental figure in the show’s enduring success.

On the Season 21 premiere of Grey's Anatomy, Meredith ( Ellen Pompeo) thwarted Catherine's ( Debbie Allen) plans. But that doesn't mean we can expect a one-dimensional villain. Showrunner Meg Marini previewed the Catherine drama to come, as well as other high-stakes conflicts, to The Hollywood Reporter.

The Season 21 premiere of ABC's Grey's Anatomy ended with a card dedicating the episode to Stephanie Leifer. Here is why.