No. 3 Ohio State faces its first major test as the Buckeyes host Iowa in a Big Ten showdown. The Buckeyes have rolled through their first four games, winning by a combined 168 points. However, Iowa's new-look offense,

Ohio State leads the all-time series between the two programs 16-3, including a 54-10 win in Columbus, the most recent meeting on Oct. 22, 2022. Iowa's last win over Ohio State occurred during the 2017 season,

Here’s what you should watch out for as Ohio State hosts Iowa in this Week 6 college football game, with our updated prediction. Ohio State vs. Iowa prediction: What to watch. 1